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NFL Pick 49ers at Packers

If there’s a better way to kick off a year of NFL betting than a Week 1 clash between the reigning champion Green Bay Packers and the defensive juggernaut San Francisco 49ers, we can’t think of it. Neither can NFL oddsmakers. This Sunday the two Super Bowl futures contenders will square off in Wisconsin.

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Although the Packers have the early edge on the NFL moneyline, the Niners have proven themselves anything but pushovers after last season’s success. Despite Green Bay’s -5 advantage in Week 1 and their 6/1 odds of winning the Super Bowl, San Francisco sits fourth on the NFL futures at 10/1. 

Jim Harbaugh’s lauded defense will have to fire on all cylinders to limit the Aaron Rodgers-led Packers attack, but if any team can come up with answer for the 2011 MVP, it’s quite likely them.

Although the Sunday slate will carry with it all the excitement of opening weekend, it’s hard not to focus on the headlining matchup between Super Bowl contenders. There are few sure things in the NFL these days, but when the afternoon bout between San Francisco and Green Bay kicks off, you may be staring at one of them.

One can’t help but to think that the packers at home -5 points is a good bet.

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Saturday, September 8th, 2012 NFL Betting 2012

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